Like CBD, CBDA suppresses nausea and vomiting in rats and shrews through the serotonin receptor (5HT1A), and also decreases intestinal motility, suggesting that CBDA plays a role in regulating nausea, for example, in patients receiving chemotherapy. CBD and CBDA are believed to cause their characteristic effects by activating our serotonin 5-HT1A receptors. You've probably heard of serotonin, as it is a vital neurotransmitter in our brain that is closely involved in regulating mood, sleep, anxiety, and even nausea. CBDa is one of the 113 compounds estimated to be known as cannabinoids in the cannabis plant.
Simply put, COX-2 is an enzyme that plays a role in the development of pro-inflammatory compounds called prostaglandins. This enzyme is the target of nonsteroidal anti-inflammatory drugs (NSAIDs), such as aspirin and ibuprofen. Although cbda and cbd have similar health effects and are related, they break down in the body in completely different ways. CBDA is now emerging as a safe and sometimes more effective alternative to traditional medication or even its cannabinoid matrix.
In another study, the research team tested the effects of CBDA and ondansetron, an anti-nausea medication. For this same reason, CBDA is more thoroughly investigated as an anti-nausea medication, and one study found that CBDA is more effective in reducing nausea than CBD. However, it is promising and early results indicate that CBDA may even be as effective as common SSRI antidepressants. These cannabinoids cause the effects of marijuana (THC), CBD, CBDA and other cannabinoid products that users enjoy.
These side effects are more likely to occur if you take large doses of CBDA or use the cannabinoid frequently throughout the day. Researchers at the University of Guelph in Ontario analyzed the effects of CBD compared to CBDA on different types of vomiting and nausea. Often, cannabinoids work even better in conjunction with other cannabinoids and compounds, a phenomenon known as the entourage effect. Another study found that CBDA was a thousand times more potent than CBD for anti-nausea and anxiety effects.
Most of the possible side effects of CBDA are mild, since the cannabinoid is not very active in the body (bioactive) compared to CBD. While experiments performed on Petri dishes cannot be compared to clinical trials in humans, the cannabinoid did show some positive effects against a highly invasive form of breast cancer. So what is CBDA? Cannabidiolic acid (CBDA) is the natural precursor to the cannabidiol compound (CBD).
